Which statement is NOT a feature of OA cartilage pathology?

• A. Increased activity of matrix metalloproteinases and ADAMTS enzymes
• B. Decreased collagen synthesis
• C. Thinning and eventual loss of cartilage
• D. Increased remodeling of the cartilage matrix

Answer: (D)

OA cartilage pathology is driven by an imbalance that favors breakdown of the extracellular matrix. Increased activity of matrix metalloproteinases and ADAMTS enzymes accelerates degradation of collagen and proteoglycans, weakening the cartilage structure. As a result, cartilage becomes thinner and can wear away over time. Chondrocyte activity also shifts toward less synthesis of collagen, further tipping toward loss rather than repair. Because articular cartilage is avascular, repair responses are limited, so there isn’t robust remodeling to restore normal architecture. The statement about increased remodeling doesn’t fit OA’s pattern, where degradation dominates and repair/remodeling is minimal.