Which of the following statements about intra-articular hyaluronic acid is true?

• A. It provides joint lubrication and promotes cartilage matrix synthesis
• B. It cures OA
• C. It increases blood glucose
• D. It worsens cartilage degradation

Answer: (A)

Intra-articular hyaluronic acid works by restoring the viscoelastic properties of the joint’s synovial fluid, providing better lubrication and shock absorption. This reduces friction during movement, which helps relieve pain and improve function in osteoarthritis. There is also some evidence that it may stimulate chondrocytes to produce components of the cartilage matrix, contributing to cartilage matrix synthesis, though it is not a cure for OA and cannot reverse established cartilage loss. It does not raise blood glucose, and it does not worsen cartilage degradation.