Which of the following is a TNF inhibitor?

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Multiple Choice

Which of the following is a TNF inhibitor?

Explanation:
TNF inhibitors are therapies that neutralize tumor necrosis factor alpha to block inflammatory signaling. Adalimumab is a monoclonal antibody that specifically binds TNF-alpha, preventing it from driving the inflammatory cascade. This makes it a TNF inhibitor and explains its use in dermatology for conditions like psoriasis and psoriatic arthritis. The other options act on different parts of the immune system: abatacept interferes with T-cell costimulation to dampen T-cell activation; rituximab targets CD20 on B cells to deplete them; methotrexate is an antimetabolite that broadly suppresses immune cell proliferation. Hence, they are not TNF inhibitors.

TNF inhibitors are therapies that neutralize tumor necrosis factor alpha to block inflammatory signaling. Adalimumab is a monoclonal antibody that specifically binds TNF-alpha, preventing it from driving the inflammatory cascade. This makes it a TNF inhibitor and explains its use in dermatology for conditions like psoriasis and psoriatic arthritis.

The other options act on different parts of the immune system: abatacept interferes with T-cell costimulation to dampen T-cell activation; rituximab targets CD20 on B cells to deplete them; methotrexate is an antimetabolite that broadly suppresses immune cell proliferation. Hence, they are not TNF inhibitors.

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