Which laboratory finding is commonly associated with DRESS?

• A. Neutropenia
• B. Eosinophilia
• C. Hyperkalemia
• D. Hypocalcemia

Answer: (B)

DRESS is a severe drug-induced hypersensitivity reaction that classically presents with a widespread rash, fever, facial swelling, and possible involvement of internal organs. The hallmark laboratory feature is eosinophilia, reflecting immune activation against the offending medication. Elevated eosinophils in the blood are commonly seen, and liver involvement may accompany it with raised liver enzymes. Neutropenia isn’t the typical pattern for DRESS and would steer you toward other drug reactions or bone marrow issues. Hyperkalemia and hypocalcemia aren’t characteristic findings of DRESS and would more likely point to electrolyte disturbances or renal problems rather than the eosinophil-predominant immune response that defines this condition.