Which description best matches NSAID-related cardiovascular risk mechanism?

• A. Inhibition of protective PG with vasodilation and natriuresis
• B. Inhibition of protective PG with vasoconstriction and Na/water retention leading to increased BP
• C. Increased protective PG leading to vasodilation
• D. No cardiovascular effect

Answer: (B)

The main idea is that prostaglandins protect cardiovascular and renal function by promoting vasodilation and helping the kidneys excrete salt and water. NSAIDs block COX enzymes, reducing the production of protective prostaglandins like prostacyclin and PGE2. With fewer of these prostaglandins, there is less vasodilation and less natriuresis, tilting toward vasoconstriction and sodium/water retention. This combination raises blood pressure and increases cardiovascular risk.

So the description that fits best is: inhibition of protective prostaglandins with vasoconstriction and Na/water retention leading to increased blood pressure. The other options imply increased prostaglandin activity or no effect, which isn’t how NSAIDs influence the CV system.