What is the weekly dose range for methotrexate?

• A. 2.5-10 mg
• B. 7.5-25 mg
• C. 25-50 mg
• D. 50-100 mg

Answer: (B)

Methotrexate is used at low, once-weekly doses for inflammatory skin and joint conditions, not daily. The typical range is from seven and a half to twenty-five milligrams per week. Starting around 7.5 mg weekly allows a gradual buildup of the anti-inflammatory effect while keeping toxicity manageable. If response and tolerance are good, the dose can be increased, usually up to 25 mg weekly, to achieve better control of the disease. This weekly schedule helps minimize adverse effects related to continuous daily exposure and contrasts with cancer regimens, where much higher doses are used and toxicity management is more intensive.