What is the correct subcutaneous dosing for Etanercept as listed?

• A. 50 mg every other week
• B. 25 mg weekly
• C. 100 mg weekly
• D. 50 mg weekly

Answer: (D)

Etanercept is used as a TNF inhibitor given by subcutaneous injection, and the standard maintenance dose for most adults is 50 mg once weekly. This schedule maintains steady drug levels to effectively dampen inflammatory signaling while balancing safety. An alternative of 25 mg twice weekly is sometimes used and would total 50 mg per week, but the option listed as 50 mg weekly aligns with the common labeling and practice. Dosing 50 mg every other week lowers the average weekly exposure and may reduce disease control; 25 mg weekly provides only half the typical weekly exposure and is usually insufficient; 100 mg weekly doubles the standard exposure and increases risk without proven additional benefit.