NSAIDs are avoided during which stage of pregnancy?

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Multiple Choice

NSAIDs are avoided during which stage of pregnancy?

Explanation:
NSAIDs inhibit prostaglandin synthesis by blocking COX enzymes. In the third trimester, prostaglandins keep the ductus arteriosus open and support fetal renal blood flow (which maintains amniotic fluid). Reducing prostaglandins in late pregnancy can cause premature closure of the ductus arteriosus, leading to increased fetal afterload, potential pulmonary hypertension, and can also decrease fetal urine output, risking oligohydramnios. These risks are why NSAIDs are avoided in the third trimester.

NSAIDs inhibit prostaglandin synthesis by blocking COX enzymes. In the third trimester, prostaglandins keep the ductus arteriosus open and support fetal renal blood flow (which maintains amniotic fluid). Reducing prostaglandins in late pregnancy can cause premature closure of the ductus arteriosus, leading to increased fetal afterload, potential pulmonary hypertension, and can also decrease fetal urine output, risking oligohydramnios. These risks are why NSAIDs are avoided in the third trimester.

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