NSAID GI complications mechanism due to COX inhibition.

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Multiple Choice

NSAID GI complications mechanism due to COX inhibition.

Explanation:
NSAIDs block COX enzymes, which reduces production of protective prostaglandins in the gastric mucosa. These prostaglandins normally stimulate mucus and bicarbonate secretion and help maintain blood flow to the mucosa. When their levels fall, the mucus barrier weakens and the mucosa becomes more vulnerable to acid injury, leading to GI complications. That’s why the correct mechanism is a decrease in mucus synthesis. The other options describe increased protection or no change, which wouldn’t explain how NSAIDs cause mucosal injury.

NSAIDs block COX enzymes, which reduces production of protective prostaglandins in the gastric mucosa. These prostaglandins normally stimulate mucus and bicarbonate secretion and help maintain blood flow to the mucosa. When their levels fall, the mucus barrier weakens and the mucosa becomes more vulnerable to acid injury, leading to GI complications. That’s why the correct mechanism is a decrease in mucus synthesis. The other options describe increased protection or no change, which wouldn’t explain how NSAIDs cause mucosal injury.

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