Naproxen ER dose is

• A. 750-1000 mg PO daily
• B. 250-500 mg PO BID
• C. 500-750 mg PO daily
• D. 1000-1500 mg PO weekly

Answer: (A)

Extended-release formulations are designed to deliver the medicine over a full day, so the total daily dose is set higher than immediate-release products but given in a way that keeps levels steadier and adherence easier. For Naproxen ER, the total daily dose is typically 750 to 1000 mg. In practice, this is taken as a single daily amount (or as directed by the product), aiming to provide effective pain and inflammation control while staying within a safer daily limit. Going up to 1000 mg per day balances efficacy with safety, particularly regarding gastrointestinal and kidney risks that NSAIDs carry. Dosing outside this daily range isn’t typical for Naproxen ER, and dosing far less often (like weekly) would not provide continuous relief.