Nabumetone dosing typically ranges in which daily dose?

• A. 500-1000 mg PO daily
• B. 1000-2000 mg PO daily in 1-2 divided doses
• C. 100-200 mg daily
• D. 3000-4000 mg daily

Answer: (B)

Nabumetone is dosed to balance anti-inflammatory effect with safety, and the typical adult range is 1,000 to 2,000 mg per day, taken in one or two divided doses. Starting at about 1,000 mg daily and increasing to up to 2,000 mg daily as needed helps maintain consistent pain and inflammation control while reducing peak-related GI upset. Dosing below this range is usually less effective for inflammatory conditions, while doses above 2,000 mg daily raise safety concerns without added benefit. Therefore, the best answer is 1,000–2,000 mg per day in 1–2 divided doses.