Live vaccines are contraindicated in patients treated with which class of biologic agents?

Unlock all questions

This demo includes only 20 questions. Upgrade to access hundreds of questions, flashcards, exam simulations, and disable ads.

Full question bankExam simulationsFlashcards
From $24.99Unlock all

Prepare for the Dermatology Week 1 Exam with comprehensive study materials. Practice with detailed questions, flashcards, and expert explanations. Boost your knowledge and confidence for the exam!

Multiple Choice

Live vaccines are contraindicated in patients treated with which class of biologic agents?

Explanation:
Blocking TNF-α disrupts the body's ability to contain intracellular pathogens and mount effective granulomatous and cell-mediated responses. Live vaccines contain replicating organisms, so in someone taking TNF inhibitors these vaccine strains can cause vaccine-associated disease or disseminate, posing a real safety risk. This is why live vaccines are avoided in patients on TNF inhibitors. The other biologics also suppress immunity, but the risk of disseminated disease from a live vaccine is most pronounced with TNF blockade due to its central role in granuloma formation and control of intracellular pathogens.

Blocking TNF-α disrupts the body's ability to contain intracellular pathogens and mount effective granulomatous and cell-mediated responses. Live vaccines contain replicating organisms, so in someone taking TNF inhibitors these vaccine strains can cause vaccine-associated disease or disseminate, posing a real safety risk. This is why live vaccines are avoided in patients on TNF inhibitors. The other biologics also suppress immunity, but the risk of disseminated disease from a live vaccine is most pronounced with TNF blockade due to its central role in granuloma formation and control of intracellular pathogens.

More Multiple Choice Questions
Subscribe

Get the latest from Examzify

You can unsubscribe at any time. Read our privacy policy