Golimumab is marketed as Simponi. What is the subcutaneous dosing schedule?

• A. 50 mg weekly
• B. 50 mg monthly
• C. 100 mg every 2 months
• D. 25 mg monthly

Answer: (B)

Golimumab given by subcutaneous injection is used at a fixed 50 mg dose every four weeks. This monthly schedule maintains steady drug levels and consistent TNF inhibition, which matches how the product is approved and labeled. The other schedules would either push injections too often (weekly), spread a higher amount over a longer interval in a way that isn’t how the drug is dosed (100 mg every two months), or use a smaller, subtherapeutic dose (25 mg monthly). If you’re ever thinking about alternatives, the intravenous form (not SC) has a different schedule, but for subcutaneous use the standard is 50 mg every 4 weeks.