A dosing option for tocilizumab when given intravenously is?

• A. IV 4-8 mg/kg every 4 weeks
• B. SQ 162 mg every other week
• C. Oral 500 mg daily
• D. IM 80 mg weekly

Answer: (A)

Dosing for tocilizumab given by IV is weight-based and scheduled every 4 weeks. You start at 4 mg/kg, and if the response isn’t adequate after at least 4 weeks, you can increase to 8 mg/kg per infusion, up to a maximum per infusion. This is the regimen that matches an intravenous administration, spaced every 4 weeks.

The other routes use different regimens: the subcutaneous form is given as a fixed 162 mg dose on a weekly or every-other-week schedule, not by weight-based IV dosing; oral and intramuscular routes are not standard options for tocilizumab in this context.